Liverpool, who have lost their last four matches, are looking to bridge the gap with league leaders Manchester United in the North West Derby.
Liverpool manager Rafael Benitez will give his injured trio of Steven Gerrard, Fernando Torres and Glen Johnson every chance to prove their fitness.
Gerrard is the biggest concern of the groin injury victims but he received treatment on Friday, and that will continue right up until the Anfield match.
Torres and Johnson are much closer to being confirmed in the starting line-up ahead of the match but winger Albert Riera (hamstring) and defenders Martin Kelly (ankle) and Sotirios Kyrgiakos (knee) are out and midfielder Alberto Aquilani - who played for the reserves on Wednesday - will not be considered.
Wayne Rooney remains a doubt for Manchester United.
The United striker has been out with a calf injury since England's World Cup qualifier in Ukraine a fortnight ago.
Manager Sir Alex Ferguson is hopeful the former Everton star will be fit to feature on Merseyside but admits it is far from certain.
Veteran Ryan Giggs is poised to return after suffering a knock in last week's defeat of Bolton Wanderers and Patrice Evra has overcome a heel problem.
Darren Fletcher (groin) is another doubt while Park Ji-Sung (knee) is set for a couple of weeks on the sidelines.
Liverpool: Reina, Johnson, Carragher, Agger, Skrtel, Aurelio, Insua, Mascherano, Babel, Lucas, Kuyt, Benayoun, Gerrard, Torres, Voronin, Ngog, Spearing, Plessis, Dossena, Cavalieri.
Manchester United: Van der Sar, Foster, Kuszczak, Neville, O'Shea, Brown, Ferdinand, Vidic, J Evans, Evra, Valencia, Carrick, Scholes, Anderson, Giggs, Berbatov, Owen, Welbeck, Macheda, Nani, Fabio, Rafael, Fletcher, Rooney.
I'm praying to all the stars and Iker's beard that they can play!